Isothiazolones

General Information
Isothiazolones are Preservatives. The toxicology of the active ingredients in Kathon™ CG/ICP preservatives have been assessed in extensive clinical and nonclinical testing and the results of these studies have demonstrated that Kathon™ CG/ICP preservatives do not present a mutagenic, carcinogenic, or teratogenic risk to humans.

However, like all preservatives, at higher than recommended use-level concentrations, Kathon™ CG/ICP can be harmful and cause skin irritation and/or skin sensitization among other things. The use of Kathon™ CG/ICP at recommended use levels is safe.

Substitute for Sodium Azide

 *   Isothiazolone   biocides have been used for microbial control in a variety of industrial water treatment applications.


 * Two of the most widely used isothiazolinone biocides are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon™.


 * Kathon™ is supplied to manufacturers as a concentrated stock solution containing from 10-15% of CMIT/MIT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones.
 * These are  highly effective preservatives approved for use by the U.S. Environmental Protection Agency (EPA) in a wide variety of household and industrial products.
 *  Isothiazolones  exhibit outstanding antimicrobial activity against gram-positive and gram-negative bacteria, yeasts and molds.

DOW chemical information